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30 µM conolidine produced a stereotypical influence on network behaviour dominated by extremely synchronous and periodic community bursting of regular length with comprehensive absence of solitary spiking (Fig. 1a). This effects is reflected in quantifiable network features, including an increase in indicate firing prices within bursts relative
Importantly, these receptors ended up uncovered to are actually activated by a wide array of endogenous opioids in a concentration comparable to that observed for activation and signaling of classical opiate receptors. Subsequently, these receptors had been uncovered to own scavenging activity, binding to and lowering endogenous levels of opiates a